Glycine → N-[(allyloxy)carbonyl]glycine

HRID 34279

Reaktionsgleichung

Reaktionsgleichung von HRID 34279
[CH2:1]([O:4][C:5](Cl)=[O:6])[CH:2]=[CH2:3].[NH2:8][CH2:9][C:10]([OH:12])=[O:11]>O.[OH-].[Na+]>[CH2:1]([O:4][C:5]([NH:8][CH2:9][C:10]([OH:12])=[O:11])=[O:6])[CH:2]=[CH2:3]

Komponenten

5

Edukt 2

HCID 750GlycineHCID 18052Allyl chloroformate

Produkt 1

HCID 11964402N-[(allyloxy)carbonyl]glycine

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 14798Sodium HydroxideLösungsmittel

Versuchsvorschrift

At 0°, 12 ml of chloroformic acid allyl ester are added dropwise to a solution of 7.51 g of glycine in 20 ml of water and 44 ml of 5N NaOH solution. The suspension is then stirred for 16 hours at room temperature. After removing the insoluble material by filtration, the filtrate is diluted with 100 ml of water and washed twice with CH2Cl2. The aqueous phase is adjusted to pH 2 with 4N HCl and extracted twice with CH2Cl2. The combined organic extracts are washed once with brine, dried over MgSO4 and concentrated by evaporation to form the white crystals of the title compound.

Aufarbeitung

  1. customAfter removing the insoluble material
  2. filtrationby filtration
  3. additionthe filtrate is diluted with 100 ml of water
  4. washwashed twice with CH2Cl2
  5. extractionextracted twice with CH2Cl2
  6. washThe combined organic extracts are washed once with brine
  7. dry with materialdried over MgSO4
  8. concentrationconcentrated by evaporation

Quellen und Nachweise

ORD-Eintrag
ord-9a103a7e86b8409ea9662cee16a2dda8
Quelldatensatz
uspto-grants-1988_08
Patentnummer
US04761408

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