4-Aminopyridine → 4-Acetamidopyridine acetate

Reaktionsgleichung

[NH2:1][C:2]1[CH:7]=[CH:6][N:5]=[CH:4][CH:3]=1.[C:8]([O:11][C:12](=[O:14])[CH3:13])(=[O:10])[CH3:9]>>[C:8]([OH:11])(=[O:10])[CH3:9].[C:12]([NH:1][C:2]1[CH:7]=[CH:6][N:5]=[CH:4][CH:3]=1)(=[O:14])[CH3:13]

Komponenten

Edukt 2

HCID 17274-Aminopyridine

HCID 7918Acetic Anhydride

Produkt 1

HCID 679231134-Acetamidopyridine acetateAusbeute 88,3 %

Reaktionsbedingungen

Temperatur: 100 °C

Versuchsvorschrift

4-Aminopyridine (101.28 g) and acetic anhydride (110 g) were mixed neat and heated at 100° C. for 1/2 h. The solidified reaction mixture was triturated with acetone, filtered off, and washed with ether to afford 186.48 g of title compound as a white solid in two crops.

Aufarbeitung

customThe solidified reaction mixture
customwas triturated with acetone
filtrationfiltered off
washwashed with ether

Quellen und Nachweise

ORD-Eintrag: ord-70630576f7fa4fdf9a289b0a26d56d9a
Quelldatensatz: uspto-grants-1991_10
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US05053413

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