Hydrochloric Acid → Toluene, alpha-chloro-2,3,4-trimethoxy-

HRID 344708

Reaktionsgleichung

Reaktionsgleichung von HRID 344708
[CH3:1][O:2][C:3]1[C:10]([O:11][CH3:12])=[C:9]([O:13][CH3:14])[CH:8]=[CH:7][C:4]=1[CH2:5]O.[ClH:15]>O>[CH3:1][O:2][C:3]1[C:10]([O:11][CH3:12])=[C:9]([O:13][CH3:14])[CH:8]=[CH:7][C:4]=1[CH2:5][Cl:15]

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 123571(2,3,4-Trimethoxyphenyl)methanol

Produkt 1

HCID 97491Toluene, alpha-chloro-2,3,4-trimethoxy-

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Reaktionsbedingungen

Temperatur
0 °C

Versuchsvorschrift

5.0 g (4.34 mmols) of 2,3,4-trimethoxybenzyl alcohol was dropwise added to 10 ml of conc. hydrochloric acid under stirring at 0° C. The mixture was stirred at 0° C. for further 5 minutes. After the reaction, water was added to the mixture followed by extraction of the solution with diethyl ether. The diethyl ether layer was dried over anhydrous sodium sulfate, and the solvent was evaporated under reduced pressure to afford 4.80 g of 2,3,4-trimethoxybenzyl chloride as a crude product.

Aufarbeitung

  1. stirringThe mixture was stirred at 0° C. for further 5 minutes
  2. additionwas added to the mixture
  3. extractionfollowed by extraction of the solution with diethyl ether
  4. dry with materialThe diethyl ether layer was dried over anhydrous sodium sulfate
  5. customthe solvent was evaporated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-a3a565d166b2461da24bbc4b59201e1e
Quelldatensatz
uspto-grants-1991_10
Patentnummer
US05053408

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