Urea → 6,7,8-Trimethoxyquinazoline-2,4(1H,3H)-dione

HRID 344712Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 344712
[CH3:1][O:2][C:3]1[C:11]([O:12][CH3:13])=[C:10]([O:14][CH3:15])[CH:9]=[C:5]([C:6]([OH:8])=O)[C:4]=1[NH2:16].[NH2:17][C:18](N)=[O:19]>O>[CH3:15][O:14][C:10]1[CH:9]=[C:5]2[C:4](=[C:3]([O:2][CH3:1])[C:11]=1[O:12][CH3:13])[NH:16][C:18](=[O:19])[NH:17][C:6]2=[O:8]

Komponenten

4

Edukt 2

HCID 1176UreaHCID 966023,4,5-Trimethoxyanthranilic acid

Produkt 1

HCID 57434216,7,8-Trimethoxyquinazoline-2,4(1H,3H)-dioneAusbeute 45,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Reaktionsbedingungen

Temperatur
145 °C

Versuchsvorschrift

A mixture of 4.94 g (21.7 mmols) of 3,4,5-trimethoxyanthranilic acid and 15.15 g (249.8 mmols) of urea was heated at 145° C for an hour with stirring. After cooling, water was added and the mixture was heated at the boiling point with stirring. The solid was taken out by filtration and dried to afford 2.47 g (yield: 45%) of 6,7,8-trimethoxyquinazoline-2,4-dione.

Aufarbeitung

  1. temperatureAfter cooling
  2. temperaturethe mixture was heated at the boiling point
  3. stirringwith stirring
  4. filtrationThe solid was taken out by filtration
  5. customdried

Quellen und Nachweise

ORD-Eintrag
ord-a2fb4af130ef44948c9087476214cf59
Quelldatensatz
uspto-grants-1991_10
Patentnummer
US05053408

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