Methyl p-toluenesulfonate → 1,1-Dimethyl-3-hydroxypiperidinium p-toluenesulfonate

HRID 344782

Reaktionsgleichung

Reaktionsgleichung von HRID 344782
[CH3:1][N:2]1[CH2:7][CH2:6][CH2:5][CH:4]([OH:8])[CH2:3]1.[C:9]1([CH3:20])[CH:14]=[CH:13][C:12]([S:15]([O:18]C)(=[O:17])=[O:16])=[CH:11][CH:10]=1>CC(C)=O>[C:9]1([CH3:20])[CH:10]=[CH:11][C:12]([S:15]([O-:18])(=[O:16])=[O:17])=[CH:13][CH:14]=1.[CH3:1][N+:2]1([CH3:9])[CH2:7][CH2:6][CH2:5][CH:4]([OH:8])[CH2:3]1

Komponenten

4

Edukt 2

HCID 6645Methyl p-toluenesulfonateHCID 980163-Piperidinol, 1-methyl-

Produkt 1

HCID 150522081,1-Dimethyl-3-hydroxypiperidinium p-toluenesulfonateAusbeute 164,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 180AcetoneLösungsmittel

Versuchsvorschrift

In 20 ml of acetone was dissolved 2.30 g of 1-methyl-3-piperidinol, and 3.72 g of methyl p-toluenesulfonate was added dropwise to the resulting solution. The mixture was stirred at room temperature, heated under reflux, and cooled to precipitate crystals. The crystals were collected by filtration and dried to give 4.94 g of the desired product, m.p. 125°-127° C. (decomp.).

Aufarbeitung

  1. additionwas added dropwise to the resulting solution
  2. temperatureheated
  3. temperatureunder reflux
  4. temperaturecooled
  5. customto precipitate crystals
  6. filtrationThe crystals were collected by filtration
  7. customdried

Quellen und Nachweise

ORD-Eintrag
ord-250ba9a0ebc94da1951455139c8420cc
Quelldatensatz
uspto-grants-1991_10
Patentnummer
US05053402

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