4-Bromoaniline → 2-Butenamide, N-(4-bromophenyl)-3-methyl-

To a solution of 9.48 g (80 mmol) of 3,3-dimethylacryloyl chloride in 200 ml of dry THF was added with vigorous shaking a solution of 13.76 g (80 mmol) of 4-bromoaniline in 300 ml of dry THF. The mixture was stood at room temperature for 2 h and then treated with 80 g of ice followed by 200 ml of hexane. The organic layer was separated and the aqueous layer was extracted with 2×50 ml of hexanes. The organic layers were combined and washed successively with 30 ml of water and 2×30 ml of saturated NaCl solution and then dried (MgSO4). The solvent was removed in vacuo and the residue purified by recrystallization from an ethyl acetate and hexanes mixture to give the title compound as colorless crystals. PMR (CDCl3): & 1.91 (3H, s), 2.23 (3H, s), 5.73 (1H, broad s), 7.38-7.55 (5H, m).

1. customThe organic layer was separated
2. extractionthe aqueous layer was extracted with 2×50 ml of hexanes
3. washwashed successively with 30 ml of water and 2×30 ml of saturated NaCl solution
4. dry with materialdried (MgSO4)
5. customThe solvent was removed in vacuo
6. customthe residue purified by recrystallization from an ethyl acetate and hexanes mixture

ORD-Eintrag

ord-a74c075dd4254bb0a7c93044512c7ee6

Quelldatensatz

uspto-grants-1991_10

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US05053523