Trimethyl orthoformate → HCID 11008070, Verbindung

HRID 345209

Reaktionsgleichung

Reaktionsgleichung von HRID 345209
[OH:1][CH2:2][C:3](C)([CH3:6])[CH:4]=O.[CH:8]([O:13][CH3:14])([O:11][CH3:12])OC.Cl.O1CCOCC1.O(C)[Na]>CO>[CH3:14][O:13][CH:8]([O:11][CH3:12])[C:3]([CH3:6])([CH3:4])[CH2:2][OH:1]

Komponenten

6

Edukt 4

HCID 9005Trimethyl orthoformateHCID 116993-Hydroxy-2,2-dimethylpropionaldehydeHCID 204431481,4-Dioxane hydrochlorideHCID 178418582HCID 178418582, Verbindung

Produkt 1

HCID 11008070HCID 11008070, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

A solution of 24.4 g (0.24 mol) of 3-hydroxy-2,2-dimethylpropanal (Aldrich), 26 g (0.25 mol) of trimethyl orthoformate, and 0.5 mL of 6.8 N HCl/dioxane in 300 mL of methanol was allowed to stand at room temperature overnight. A slight excess of NaOCH3 was added and the solvent evaporated at reduced pressure. The residue was dissolved in ether and the mixture filtered. After evaporation of solvent and fractionation twice through a 15 cm Vigreux column, the product was obtained as a water white oil, bp 43°-48°/0.2mm, 18.5 g (52%).

Aufarbeitung

  1. customthe solvent evaporated at reduced pressure
  2. dissolutionThe residue was dissolved in ether
  3. filtrationthe mixture filtered
  4. customAfter evaporation of solvent and fractionation twice through a 15 cm Vigreux column
  5. customthe product was obtained as a water white oil, bp 43°-48°/0.2mm, 18.5 g (52%)

Quellen und Nachweise

ORD-Eintrag
ord-2c753e33e993440b831c89dc3bb7c67a
Quelldatensatz
uspto-grants-1991_10
Patentnummer
US05055613

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