Hydrochloric Acid → N,N-Dibenzyl-O-carbamylhydroxylamine

HRID 345621

Reaktionsgleichung

Reaktionsgleichung von HRID 345621
[CH2:1]([N:8]([CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)[OH:9])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl.[O-:18][C:19]#[N:20].[K+]>CO.O>[CH2:10]([N:8]([CH2:1][C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1)[O:9][C:19](=[O:18])[NH2:20])[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1

Komponenten

6

Edukt 3

HCID 313Hydrochloric AcidHCID 69297DibenzylhydroxylamineHCID 11378442Potassium cyanate

Produkt 1

HCID 15180714N,N-Dibenzyl-O-carbamylhydroxylamine

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 887MethanolLösungsmittelHCID 962WaterLösungsmittel2×

Versuchsvorschrift

A stirred suspension of 10.70 g of N,N-dibenzylhydroxylamine in 25 ml of methanol is admixed dropwise with a solution of 4.53 ml conc. hydrochloric acid in 10 ml of water. A solution of 4.06 g of potassium cyanate in 15 ml of water is then added and the resulting suspension is stirred at room temperature for 3 hours. The crude product is removed by filtration and further purified by liquid chromatography to afford the title compound as a white solid; m.p. 127°-29° C.

Aufarbeitung

  1. customThe crude product is removed by filtration
  2. customfurther purified by liquid chromatography

Quellen und Nachweise

ORD-Eintrag
ord-c6e69c66052b4a1caae6615e35fa0218
Quelldatensatz
uspto-grants-1991_10
Patentnummer
US05057610

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