6-Benzyl-octahydropyrrolo[3,4-b][1,4]oxazine → Octahydropyrrolo[3,4-b][1,4]oxazine

HRID 345790Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 345790
C([N:8]1[CH2:16][CH:15]2[CH:10]([NH:11][CH2:12][CH2:13][O:14]2)[CH2:9]1)C1C=CC=CC=1>CO.[Pd]>[CH:15]12[CH2:16][NH:8][CH2:9][CH:10]1[NH:11][CH2:12][CH2:13][O:14]2

Komponenten

4

Edukt 1

HCID 150699806-Benzyl-octahydropyrrolo[3,4-b][1,4]oxazine

Produkt 1

HCID 15069981Octahydropyrrolo[3,4-b][1,4]oxazine

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

7.2 g (33 mmol) of 8-benzyl-2-oxa-5,8-diazabicyclo[4.3.0]nonane are hydrogenated in 400 ml of methanol with 2.5 g of palladium-on-active charcoal (10% of Pd) under 50 bar at 100° C. The catalyst is filtered off with suction, the filtrate is concentrated and the residue is distilled.

Aufarbeitung

  1. filtrationThe catalyst is filtered off with suction
  2. concentrationthe filtrate is concentrated
  3. distillationthe residue is distilled

Quellen und Nachweise

ORD-Eintrag
ord-3961f500db6f4ab7b1d60f68f0c5e15b
Quelldatensatz
uspto-grants-1991_10
Patentnummer
US05059597

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