Ethyl chloroformate → N-(1,1-dimethoxyprop-2-yl)urethane

HRID 345816

Reaktionsgleichung

Reaktionsgleichung von HRID 345816
Cl[C:2]([O:4][CH2:5][CH3:6])=[O:3].[CH3:7][O:8][CH:9]([O:13][CH3:14])[CH:10]([NH2:12])[CH3:11].[OH-].[Na+]>C1(C)C=CC=CC=1.O>[CH3:7][O:8][CH:9]([O:13][CH3:14])[CH:10]([NH:12][C:2]([O:4][CH2:5][CH3:6])=[O:3])[CH3:11]

Komponenten

6

Edukt 3

HCID 10928Ethyl chloroformateHCID 14798Sodium HydroxideHCID 936582,2-Dimethoxy-1-methylethylamine

Produkt 1

HCID 15069987N-(1,1-dimethoxyprop-2-yl)urethane

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 1140TolueneLösungsmittel

Versuchsvorschrift

80 g (0.73 mol) of ethyl chloroformate are added dropwise to 86.2 g (0.72 mol) of 2-aminopropionaldehyde dimethyl acetal in 350 ml of toluene and 32 g (0.8 mol) of NaOH in 300 ml of water. The mixture is stirred at room temperature for a further 2 hours, the organic phase is separated off, the aqueous phase is extracted with toluene and the toluene solutions are dried over K2CO3. The solution is concentrated and the residue is distilled.

Aufarbeitung

  1. customthe organic phase is separated off
  2. extractionthe aqueous phase is extracted with toluene
  3. dry with materialthe toluene solutions are dried over K2CO3
  4. concentrationThe solution is concentrated
  5. distillationthe residue is distilled

Quellen und Nachweise

ORD-Eintrag
ord-ae41be02a0814be8befcd23c5a66691d
Quelldatensatz
uspto-grants-1991_10
Patentnummer
US05059597

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