5-Fluoro-4-methyl-2-nitrobenzoic acid → 2-Amino-5-fluoro-4-methylbenzoic acid

HRID 34591Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 34591
[N+:1]([C:4]1[CH:12]=[C:11]([CH3:13])[C:10]([F:14])=[CH:9][C:5]=1[C:6]([OH:8])=[O:7])([O-])=O>O1CCOCC1.[Pd]>[NH2:1][C:4]1[CH:12]=[C:11]([CH3:13])[C:10]([F:14])=[CH:9][C:5]=1[C:6]([OH:8])=[O:7]

Komponenten

4

Edukt 1

HCID 136574495-Fluoro-4-methyl-2-nitrobenzoic acid

Produkt 1

HCID 136574502-Amino-5-fluoro-4-methylbenzoic acid

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

525 g of 2-nitro-4-methyl-5-fluoro-benzoic acid are hydrogenated in 3 l of dioxane with 50 g of 5% strength Pd-C catalyst at 30°-40° under 20-30 bar. The catalyst is filtered off with suction and the solution is poured onto water. The crystals which have precipitated are filtered off with suction and dried. Yield: 357 g (80.1% of theory), melting point: 201°-202° C.

Aufarbeitung

  1. filtrationThe catalyst is filtered off with suction
  2. additionthe solution is poured onto water
  3. customThe crystals which have precipitated
  4. filtrationare filtered off with suction
  5. customdried

Quellen und Nachweise

ORD-Eintrag
ord-e46f2afba65f4f8c8a73c8e0d2d83634
Quelldatensatz
uspto-grants-1988_08
Patentnummer
US04762844

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