Bromine → 3-Bromo-4-fluorobenzaldehyde

A solution of 4-fluorobenzaldehyde (49.6 g) in dry dichloromethane (20 cm3) was added to a cooled (0° C.) suspension of powdered aluminium trichloride (90.4 g) in dry dichloromethane (100 cm3). Bromine (70.4 g) was added, and the mixture heated at the reflux temperature of 16 hours. After cooling, the reaction mixture was carefully poured onto ice and extracted with dichloromethane. The combined organic layers were washed with saturated sodium metabisulphite solution, water and brine, then dried over anhydrous magnesium sulphate. Evaporation of the solvent under reduced pressure gave a dark red oil, which was purified by distillation under reduced pressure, using a 4" Vigreux column to give 3-bromo-4-fluorobenzaldehyde (45.7 g) as an oil, boiling point 85°-108° C. at 8 mmHg.

1. temperaturea cooled
2. temperaturethe mixture heated at the reflux temperature of 16 hours
3. temperatureAfter cooling
4. additionthe reaction mixture was carefully poured onto ice
5. extractionextracted with dichloromethane
6. washThe combined organic layers were washed with saturated sodium metabisulphite solution, water and brine
7. dry with materialdried over anhydrous magnesium sulphate
8. customEvaporation of the solvent under reduced pressure
9. customgave a dark red oil, which
10. distillationwas purified by distillation under reduced pressure

ORD-Eintrag

ord-51f7bccd211f473794c0bb87181f8215

Quelldatensatz

uspto-grants-1988_08

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US04762835