Diethyl Ether → 2-(4-Diethoxymethylphenyl)ethanol

To a solution of 4-(diethoxymethyl)benzaldehyde (5.0 g, 24 mmol) in ether (65 ml), cooled to -10° C., was added dropwise a 1.5M toluene-THF methylmagnesium bromide solution (64 ml, 96 mmol) at such a rate that the temperature remains below 0° C. After the addition the reaction was quenched with saturated ammonium chloride (80 ml) and the solution was diluted with water (50 ml) and extracted with ether (2×75 ml). The combined extracts were washed with water (50 ml) and brine (50 ml), dried over sodium sulfate and concentrated in vacuo, leaving present title product (5.2 g, 97%) as an oil.

1. customremains below 0° C
2. additionAfter the addition the reaction
3. customwas quenched with saturated ammonium chloride (80 ml)
4. additionthe solution was diluted with water (50 ml)
5. extractionextracted with ether (2×75 ml)
6. washThe combined extracts were washed with water (50 ml) and brine (50 ml)
7. dry with materialdried over sodium sulfate
8. concentrationconcentrated in vacuo

ORD-Eintrag

ord-f5047be61d054797ad1324dbbb4741ef

Quelldatensatz

uspto-grants-1991_10

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US05061717