Pyrrolidine → BOC-L-methionyl-pyrrolidine

Reaktionsgleichung

[C:1]([NH:8][C@H:9]([C:14]([OH:16])=O)[CH2:10][CH2:11][S:12][CH3:13])([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2].[NH:17]1[CH2:21][CH2:20][CH2:19][CH2:18]1>>[C:1]([NH:8][C@H:9]([C:14]([N:17]1[CH2:21][CH2:20][CH2:19][CH2:18]1)=[O:16])[CH2:10][CH2:11][S:12][CH3:13])([O:3][C:4]([CH3:5])([CH3:6])[CH3:7])=[O:2]

Komponenten

Edukt 2

HCID 31268Pyrrolidine

HCID 89857Boc-L-methionine

Produkt 1

HCID 11034003BOC-L-methionyl-pyrrolidine

Versuchsvorschrift

2.50 g (10 mmol) BOC-methionine was coupled to 1.72 ml (20.6 mmol) pyrrolidine according to procedure B. Yield of crude product 3.38 g. The product was purified with a silica column using ethyl acetate as eluent. Yield 2.81 g (9.3 mmol, 93%).

Aufarbeitung

customThe product was purified with a silica column

Quellen und Nachweise

ORD-Eintrag: ord-b0b858eef19d47ada090bbefcb651833
Quelldatensatz: uspto-grants-2007_02
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US07173024B2

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