Water → 3-Amino-3-(3-cyclopropylmethoxy-4-difluoromethoxy-phenyl)-propionic acid methyl ester

HRID 346890Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 346890
Cl.[CH3:2][O:3][C:4](=[O:23])[CH2:5][CH:6]([NH2:22])[C:7]1[CH:12]=[CH:11][C:10]([O:13][CH:14]([F:16])[F:15])=[C:9]([O:17][CH2:18][CH:19]2[CH2:21][CH2:20]2)[CH:8]=1.O.C(=O)([O-])[O-].[Na+].[Na+]>C(Cl)Cl>[CH3:2][O:3][C:4](=[O:23])[CH2:5][CH:6]([NH2:22])[C:7]1[CH:12]=[CH:11][C:10]([O:13][CH:14]([F:15])[F:16])=[C:9]([O:17][CH2:18][CH:19]2[CH2:20][CH2:21]2)[CH:8]=1

Komponenten

5

Edukt 3

HCID 962WaterHCID 10340Sodium CarbonateHCID 669202293-amino-3-(3-cyclopropylmethoxy-4-difluoromethoxy-phenyl)-propionic acid methyl ester HCl salt

Produkt 1

HCID 588000783-Amino-3-(3-cyclopropylmethoxy-4-difluoromethoxy-phenyl)-propionic acid methyl ester

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

To a solution of 3-amino-3-(3-cyclopropylmethoxy-4-difluoromethoxy-phenyl)-propionic acid methyl ester HCl salt (540 mg 1.5 mmol) in methylene chloride (20 ml) was added water (20 ml) and sodium carbonate (160 mg, 1.5 mmol). The mixture was stirred at room temperature for 30 min then separated in separatory funnel. The organic layer was washed with water (20 ml), brine (20 ml) and dried over magnesium sulfate. The solvent was removed in vacuo. The resulted oil was used in next step without further purification.

Aufarbeitung

  1. customthen separated in separatory funnel
  2. washThe organic layer was washed with water (20 ml), brine (20 ml)
  3. dry with materialdried over magnesium sulfate
  4. customThe solvent was removed in vacuo
  5. customThe resulted oil was used in next step without further purification

Quellen und Nachweise

ORD-Eintrag
ord-c59755ac04b04760a04835bcb50b721b
Quelldatensatz
uspto-grants-2007_02
Patentnummer
US07173058B2

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