Hydrochloric Acid → Sertraline Hydrochloride

HRID 347403

Reaktionsgleichung

Reaktionsgleichung von HRID 347403
[CH3:1][NH:2][C@@H:3]1[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=2[C@H:6]([C:13]2[CH:14]=[CH:15][C:16]([Cl:20])=[C:17]([Cl:19])[CH:18]=2)[CH2:5][CH2:4]1.[ClH:21]>C(O)CCCCCC>[CH3:1][NH:2][C@@H:3]1[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=2[C@H:6]([C:13]2[CH:14]=[CH:15][C:16]([Cl:20])=[C:17]([Cl:19])[CH:18]=2)[CH2:5][CH2:4]1.[ClH:21]

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 68617Sertraline

Produkt 1

HCID 63009Sertraline HydrochlorideAusbeute 88 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8129HeptanolLösungsmittel2×

Versuchsvorschrift

A solution of 50.9 g free sertraline base in 100 ml of n-heptanol was added dropwise over a period of about 30 minutes at room temperature onto 100 ml of n-heptanol containing 14 ml of 37% aqueous hydrochloric acid. At the end of the addition a white crystalline solid starts to form. Stirring is maintained for 1 hour then the solid is filtered and washed. It is dried under vacuum. 50.1 g of sertraline hydrochloride form II are obtained in a yield of 88%.

Aufarbeitung

  1. additionAt the end of the addition a white crystalline solid starts
  2. customto form
  3. temperatureis maintained for 1 hour
  4. filtrationthe solid is filtered
  5. washwashed
  6. customIt is dried under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-82e8c74c4f1a487090487904b53da035
Quelldatensatz
uspto-grants-2007_02
Patentnummer
US07173153B2

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