Isovaleryl chloride → 1-{N-[3-(3-methylbutanamido)propyl]-tetradecanamido}-5-(4,6-dimethyl-2-pyrimidylamino)pentane

HRID 34756

Reaktionsgleichung

Reaktionsgleichung von HRID 34756
[NH2:1][CH2:2][CH2:3][CH2:4][N:5]([CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][NH:26][C:27]1[N:32]=[C:31]([CH3:33])[CH:30]=[C:29]([CH3:34])[N:28]=1)[C:6](=[O:20])[CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH3:19].[CH3:35][CH:36]([CH3:41])[CH2:37][C:38](Cl)=[O:39]>N1C=CC=CC=1>[CH3:35][CH:36]([CH3:41])[CH2:37][C:38]([NH:1][CH2:2][CH2:3][CH2:4][N:5]([CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][NH:26][C:27]1[N:28]=[C:29]([CH3:34])[CH:30]=[C:31]([CH3:33])[N:32]=1)[C:6](=[O:20])[CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH3:19])=[O:39]

Komponenten

4

Edukt 2

HCID 66054Isovaleryl chlorideHCID 143460201-[N-(3-aminopropyl)tetradecanamido]-5-(4,6-dimethyl-2-pyrimidylamino)pentane

Produkt 1

HCID 143460211-{N-[3-(3-methylbutanamido)propyl]-tetradecanamido}-5-(4,6-dimethyl-2-pyrimidylamino)pentane

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1049PyridineLösungsmittel

Versuchsvorschrift

The primary amine XV was treated with 3-methylbutanoyl chloride in pyridine in the manner described above (C). The crude product was chromatographed on a 24 g silica gel column (BioSil A) of dimensions 1 cm (id)×30 cm, developed with 30% acetone/CHCl3. Five ml fractions were collected. The pure product was found in tubes 14-22, 128 mg.

Aufarbeitung

  1. customThe crude product was chromatographed on a 24 g silica gel column (BioSil A) of dimensions 1 cm (id)×30 cm
  2. customFive ml fractions were collected

Quellen und Nachweise

ORD-Eintrag
ord-fe2d28c06bf84c46b92c4d5abeabde8a
Quelldatensatz
uspto-grants-1988_08
Patentnummer
US04762949

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