Iodoethane → 2H-1,5-Benzodiazepin-2-one, 1,3,4,5-tetrahydro-1-ethyl-
Reaktionsgleichung
[O:1]=[C:2]1[NH:8][C:7]2[CH:9]=[CH:10][CH:11]=[CH:12][C:6]=2[NH:5][CH2:4][CH2:3]1.[CH2:13](I)[CH3:14]>>[CH2:13]([N:8]1[C:7]2[CH:9]=[CH:10][CH:11]=[CH:12][C:6]=2[NH:5][CH2:4][CH2:3][C:2]1=[O:1])[CH3:14]Komponenten
3
Versuchsvorschrift
2-Oxo-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine (1.95 g, 11.96 mmol) was reacted with ethyl iodide (1.4 ml, 17.5 mmol) according to the procedure in Example 18A. The product was purified by flash chromatography on silica (eluant EtOAc); yield 1.70 g (75%).
Aufarbeitung
- customThe product was purified by flash chromatography on silica (eluant EtOAc)
Quellen und Nachweise
- ORD-Eintrag
- ord-c59cc29e10ad497786d80d9cece45616
- Quelldatensatz
- uspto-grants-2007_02
- Patentnummer
- US07176195B2
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