4-Cyclohexylphenoxy-3-(4-benzyloxyphenyl)-2-methyl-propionic acid ethyl ester → 2-(4-Cyclohexylphenoxy)-3-(4-hydroxyphenyl)-2-methyl-propionic acid ethyl ester

HRID 348327Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 348327
[CH2:1]([O:3][C:4](=[O:35])[C:5]([O:22][C:23]1[CH:28]=[CH:27][C:26]([CH:29]2[CH2:34][CH2:33][CH2:32][CH2:31][CH2:30]2)=[CH:25][CH:24]=1)([CH3:21])[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([O:13]CC2C=CC=CC=2)=[CH:9][CH:8]=1)[CH3:2]>C(OCC)(=O)C.[Pd]>[CH2:1]([O:3][C:4](=[O:35])[C:5]([O:22][C:23]1[CH:24]=[CH:25][C:26]([CH:29]2[CH2:34][CH2:33][CH2:32][CH2:31][CH2:30]2)=[CH:27][CH:28]=1)([CH3:21])[CH2:6][C:7]1[CH:8]=[CH:9][C:10]([OH:13])=[CH:11][CH:12]=1)[CH3:2]

Komponenten

4

Edukt 1

HCID 693531254-Cyclohexylphenoxy-3-(4-benzyloxyphenyl)-2-methyl-propionic acid ethyl ester

Produkt 1

HCID 693147822-(4-Cyclohexylphenoxy)-3-(4-hydroxyphenyl)-2-methyl-propionic acid ethyl ester

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

2-(4-Cyclohexylphenoxy-3-(4-benzyloxyphenyl)-2-methyl-propionic acid ethyl ester (2.1 mmol) was dissolved in ethyl acetate (30 mL) and treated with 5% palladium on carbon (300 mg), and stirred under an atmosphere of hydrogen for 20 h. The suspension was filtered through celite and concentrated in vacuo to an oil.

Aufarbeitung

  1. filtrationThe suspension was filtered through celite and
  2. concentrationconcentrated in vacuo to an oil

Quellen und Nachweise

ORD-Eintrag
ord-78565a71248c48e6a911dc660a0ee415
Quelldatensatz
uspto-grants-2007_02
Patentnummer
US07176224B2

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