Magnesium Chloride → HCID 178488147, Verbindung

HRID 348429

Reaktionsgleichung

Reaktionsgleichung von HRID 348429
[K].[CH3:2][O:3][C:4]1[CH:25]=[CH:24][C:7]2[NH:8][C:9]([S@:11]([CH2:13][C:14]3[C:19]([CH3:20])=[C:18]([O:21][CH3:22])[C:17]([CH3:23])=[CH:16][N:15]=3)=[O:12])=[N:10][C:6]=2[CH:5]=1.[Cl-].[Mg+2].[Cl-]>O>[CH3:23][C:17]1[CH:16]=[N:15][C:14]([CH2:13][S+:11]([O-:12])[C:9]2[NH:8][C:7]3[CH:24]=[CH:25][C:4]([O:3][CH3:2])=[CH:5][C:6]=3[N:10]=2)=[C:19]([CH3:20])[C:18]=1[O:21][CH3:22]

Komponenten

5

Edukt 3

HCID 5360315Magnesium ChlorideHCID 5462222PotassiumHCID 9568614Esomeprazole

Produkt 1

HCID 178488147HCID 178488147, VerbindungAusbeute 76,9 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Reaktionsbedingungen

Temperatur
25 °C

Versuchsvorschrift

Potassium salt of (S)-5-Methoxy-2-[(3,5-dimethyl-4-methoxy-2-pyridyl) methylsulfinyl]1-H-benzimidazole (Esomeprazole potassium) (5.2 gm) was dissolved in water (75 ml). To this solution, was added magnesium chloride solution (1.4 gm in 50 ml water), and then the contents were stirred for 1 hour at 25° C. The solid precipitated was filtered, washed with water and dried under vacuum for 12 hours at 40° C. to obtain 4.0 gm of esomeprazole magnessium dihydrate (enantiomeric excess: 99.7%).

Aufarbeitung

  1. customThe solid precipitated
  2. filtrationwas filtered
  3. washwashed with water
  4. customdried under vacuum for 12 hours at 40° C.

Quellen und Nachweise

ORD-Eintrag
ord-7e116e956ae54210a4e262617ce47c1d
Quelldatensatz
uspto-grants-2007_02
Patentnummer
US07176319B2

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