Trimethyl orthoformate → Methyl 1-methyl-1H-benzo[d]imidazole-5-carboxylate

HRID 348524

Reaktionsgleichung

Reaktionsgleichung von HRID 348524
[NH2:1][C:2]1[CH:3]=[C:4]([CH:9]=[CH:10][C:11]=1[NH:12][CH3:13])[C:5]([O:7][CH3:8])=[O:6].[CH:14](OC)(OC)OC>>[CH3:13][N:12]1[C:11]2[CH:10]=[CH:9][C:4]([C:5]([O:7][CH3:8])=[O:6])=[CH:3][C:2]=2[N:1]=[CH:14]1

Komponenten

3

Edukt 2

HCID 9005Trimethyl orthoformateHCID 15586064Methyl 3-amino-4-(methylamino)benzoate

Produkt 1

HCID 965319Methyl 1-methyl-1H-benzo[d]imidazole-5-carboxylate

Versuchsvorschrift

A solution of methyl 3-amino-4-methylaminobenzoate (prepared as in DE 1990390463 A1) (2.57 g, 14 mmol) in trimethyl orthoformate (50 mL) was refluxed for 16 hours. The solvent was then removed under reduced pressure to afford 2.31 g of product.

Aufarbeitung

  1. customThe solvent was then removed under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-32dc8e7f00a3425182a33ced2a8f8734
Quelldatensatz
uspto-grants-2007_02
Patentnummer
US07176322B2

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