Reaktionsgleichung
[CH2:1]([N:5]1[C:10]2[CH:11]=[C:12]([C:20]([O:22]C)=[O:21])[CH:13]=[C:14]([C:15]3[O:16][CH:17]=[CH:18][N:19]=3)[C:9]=2[O:8][CH2:7][CH2:6]1)[CH2:2][CH2:3][CH3:4].[OH-].[K+]>CO.O>[CH2:1]([N:5]1[C:10]2[CH:11]=[C:12]([C:20]([OH:22])=[O:21])[CH:13]=[C:14]([C:15]3[O:16][CH:17]=[CH:18][N:19]=3)[C:9]=2[O:8][CH2:7][CH2:6]1)[CH2:2][CH2:3][CH3:4]Komponenten
5
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 2
Versuchsvorschrift
To a stirred solution of Methyl 4-butyl-8-(1,3-oxazol-2-yl)-3,4-dihydro-2H-1,4-benzoxazine-6-carboxylate (474 mg) in methanol (20 mL) was added potassium hydroxide (15 mL of a 1.0 M solution in water). The mixture was stirred at room temperature overnight then concentrated under reduced pressure. The residue was diluted with water and washed with ethyl acetate. The aqueous layer was acidified to pH 4 with 1 N hydrochloric acid and extracted with chloroform (4×100 mL). The combined organic extracts were dried (sodium sulfate), filtered, and concentrated under reduced pressure to give 450 mg of the title compound: 1H NMR (300 MHz, CDCl3) δ 11.60, 8.08, 7.74, 7.46, 7.37, 4.46, 3.43, 3.34, 1.62, 1.41, 0.98.
Aufarbeitung
- concentrationthen concentrated under reduced pressure
- additionThe residue was diluted with water
- washwashed with ethyl acetate
- extractionextracted with chloroform (4×100 mL)
- dry with materialThe combined organic extracts were dried (sodium sulfate)
- filtrationfiltered
- concentrationconcentrated under reduced pressure
Quellen und Nachweise
- ORD-Eintrag
- ord-6369df8879ef40acb2b705505c22d39c
- Quelldatensatz
- uspto-grants-2007_02
- Patentnummer
- US07176242B2
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