Lithium hydroxide, monohydrate → 3-{[Ethyl(propyl)amino]carbonyl}-5-(1,3-oxazol-2-yl)benzoic Acid

HRID 349092

Reaktionsgleichung

Reaktionsgleichung von HRID 349092
[CH2:1]([N:3]([CH2:21][CH2:22][CH3:23])[C:4]([C:6]1[CH:7]=[C:8]([CH:13]=[C:14]([C:16]2[O:17][CH:18]=[CH:19][N:20]=2)[CH:15]=1)[C:9]([O:11]C)=[O:10])=[O:5])[CH3:2].O.[OH-].[Li+]>O1CCCC1.CO.O.C(Cl)(Cl)Cl>[CH2:1]([N:3]([CH2:21][CH2:22][CH3:23])[C:4]([C:6]1[CH:7]=[C:8]([CH:13]=[C:14]([C:16]2[O:17][CH:18]=[CH:19][N:20]=2)[CH:15]=1)[C:9]([OH:11])=[O:10])=[O:5])[CH3:2]

Komponenten

5

Edukt 2

HCID 168937Lithium hydroxide, monohydrateHCID 21086182Methyl 3-{[ethyl(propyl)amino]carbonyl}-5-(1,3-oxazol-2-yl)benzoate

Produkt 1

HCID 210858313-{[Ethyl(propyl)amino]carbonyl}-5-(1,3-oxazol-2-yl)benzoic Acid

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 6212ChloroformLösungsmittelHCID 21892291Methanol tetrahydrofuran waterLösungsmittel

Versuchsvorschrift

To methyl 3-{[ethyl(propyl)amino]carbonyl}-5-(1,3-oxazol-2-yl)benzoate (375 mg, 1.2 mmol) in tetrahydrofuran/methanol/water (1:1:1, 9 mL) is added lithium hydroxide monohydrate (100 mg, 2.4 mmol), and the reaction is stirred at room temperature 16 h. The solution is diluted in chloroform and washed with water and saturated sodium chloride, dried (sodium sulfate), filtered, and concentrated under reduced pressure to give the title compound. ESI MS m/z 301.1 [M−H]−.

Aufarbeitung

  1. washwashed with water and saturated sodium chloride
  2. dry with materialdried (sodium sulfate)
  3. filtrationfiltered
  4. concentrationconcentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-960260c216e140af8939643ca3840351
Quelldatensatz
uspto-grants-2007_02
Patentnummer
US07176242B2

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