Succinic anhydride → HCID 57512111, Verbindung

HRID 349118

Reaktionsgleichung

Reaktionsgleichung von HRID 349118
[NH2:1][CH:2]([CH2:18][C:19]1[CH:24]=[C:23]([F:25])[CH:22]=[C:21]([F:26])[CH:20]=1)[CH:3]([OH:17])[CH2:4][NH:5][C:6]1([C:9]2[CH:14]=[CH:13][CH:12]=[C:11]([CH2:15][CH3:16])[CH:10]=2)[CH2:8][CH2:7]1.[C:27]1(=[O:33])[O:32][C:30](=[O:31])[CH2:29][CH2:28]1>C(Cl)(Cl)Cl>[F:26][C:21]1[CH:20]=[C:19]([CH:24]=[C:23]([F:25])[CH:22]=1)[CH2:18][C@H:2]([NH:1][C:27](=[O:33])[CH2:28][CH2:29][C:30]([OH:32])=[O:31])[C@H:3]([OH:17])[CH2:4][NH:5][C:6]1([C:9]2[CH:14]=[CH:13][CH:12]=[C:11]([CH2:15][CH3:16])[CH:10]=2)[CH2:8][CH2:7]1

Komponenten

4

Edukt 2

HCID 7922Succinic anhydrideHCID 210854823-Amino-4-(3,5-difluoro-phenyl)-1-[1-(3-ethyl-phenyl)-cyclopropylamino]-butan-2-ol

Produkt 1

HCID 57512111HCID 57512111, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6212ChloroformLösungsmittel

Versuchsvorschrift

To a solution of 3-Amino-4-(3,5-difluoro-phenyl)-1-[1-(3-ethyl-phenyl)-cyclopropylamino]-butan-2-ol (0.500 g, 1.387 mmol) in chloroform (7 ml) was added TEA (0.58 ml, 4.161 mmol) with stirring under nitrogen for 30 min. To this solution was added succinic anhydride (0.138 g, 1.387 mmol) and reaction was stirred overnight at 50° C. The next morning reaction mixture was concentrated in vacuo, yielding the product. (ES+: 461.2)

Aufarbeitung

  1. additionTo this solution was added
  2. stirringwas stirred overnight at 50° C
  3. customThe next morning reaction mixture
  4. concentrationwas concentrated in vacuo
  5. customyielding the product

Quellen und Nachweise

ORD-Eintrag
ord-1e1c2cf3237549f5af2fd5e8c7b88c5c
Quelldatensatz
uspto-grants-2007_02
Patentnummer
US07176242B2

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