P-Chloroacetophenone → (1S)-1-(4-chlorophenyl)ethan-1-ol

HRID 349150

Reaktionsgleichung

Reaktionsgleichung von HRID 349150
[CH3:1][C:2]([C:4]1[CH:9]=[CH:8][C:7]([Cl:10])=[CH:6][CH:5]=1)=[O:3]>O>[Cl:10][C:7]1[CH:8]=[CH:9][C:4]([C@@H:2]([OH:3])[CH3:1])=[CH:5][CH:6]=1

Komponenten

3

Edukt 1

HCID 7467P-Chloroacetophenone

Produkt 1

HCID 6950175(1S)-1-(4-chlorophenyl)ethan-1-ol

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

Washed phaseolus aureus L (green grams) 50 g. were taken into a conical flask and allowed to soak in deionised water (400 ml) for a period of 24 hr. 4-chloroacetophenone (0.500 g; 0.0032 moles) I(b) was added to the soaked phaseolus aureus L (green grams) in the above water, covered and allowed to shake for 24 hr at 15–20° C. Then the green grams were filtered off and washed with deionised water (3×100 ml). The combined filtrate was extracted with chloroform (3×500 ml). The chloroform layer was dried and the crude product obtained (340 mg). Pure 1-(4-chlorophenyl-(1S)-ethan-1-ol II(b) was obtained after column chromatography with silica gel using chloroform as eluent.

Aufarbeitung

  1. washWashed phaseolus aureus L (green grams) 50 g
  2. customwere taken into a conical flask
  3. waitto shake for 24 hr at 15–20° C
  4. filtrationThen the green grams were filtered off
  5. washwashed with deionised water (3×100 ml)
  6. extractionThe combined filtrate was extracted with chloroform (3×500 ml)
  7. dry with materialThe chloroform layer was dried
  8. customthe crude product obtained (340 mg)

Quellen und Nachweise

ORD-Eintrag
ord-dd6cbdb892504684acf7ea8a75fa791e
Quelldatensatz
uspto-grants-2007_02
Patentnummer
US07179624B2

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