Chloroform → Methyl 3-acetamido-4,5-dichlorothiophene-2-carboxylate

HRID 349428Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 349428
[C:1]([NH:4][C:5]1[CH:9]=C[S:7][C:6]=1[C:10]([O:12][CH3:13])=[O:11])(=[O:3])[CH3:2].S(Cl)([Cl:17])(=O)=O.[CH:19]([Cl:22])(Cl)Cl>>[C:1]([NH:4][C:5]1[C:9]([Cl:17])=[C:19]([Cl:22])[S:7][C:6]=1[C:10]([O:12][CH3:13])=[O:11])(=[O:3])[CH3:2]

Komponenten

4

Edukt 3

HCID 6212Chloroform2×HCID 24648Sulfuryl chlorideHCID 729216methyl 3-acetamidothiophene-2-carboxylate

Produkt 1

HCID 22139803Methyl 3-acetamido-4,5-dichlorothiophene-2-carboxylate

Reaktionsbedingungen

Temperatur
40 °C

Versuchsvorschrift

was obtained by reacting 19.9 g of methyl 3-acetylaminothiophene-2-carboxylate in 100 ml of chloroform with 17.9 ml of sulfuryl chloride (SO2Cl2) in 120 ml of chloroform by stirring at 40° C. for 2 hours and subsequently boiling under reflux conditions for 15 minutes. After the solvent had been distilled off, the residue was crystallized in ethyl acetate.

Aufarbeitung

  1. customwas obtained
  2. waitsubsequently boiling under reflux conditions for 15 minutes
  3. distillationAfter the solvent had been distilled off
  4. customthe residue was crystallized in ethyl acetate

Quellen und Nachweise

ORD-Eintrag
ord-1be62623a17a47cabd5b61e31375bf48
Quelldatensatz
uspto-grants-2007_02
Patentnummer
US07179830B2

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