8alpha-Benzyloxycarbonylamino-6-n-propylergoline → 8alpha-Amino-6-n-propylergoline

HRID 34957Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 34957
C(OC([NH:11][C@H:12]1[CH2:26][C@H:25]2[C@@H:15]([CH2:16][C:17]3[C:27]4[C:20](=[CH:21][CH:22]=[CH:23][C:24]2=4)[NH:19][CH:18]=3)[N:14]([CH2:28][CH2:29][CH3:30])[CH2:13]1)=O)C1C=CC=CC=1.[H][H]>[Pd].C(O)C>[NH2:11][C@H:12]1[CH2:26][C@H:25]2[C@@H:15]([CH2:16][C:17]3[C:27]4[C:20](=[CH:21][CH:22]=[CH:23][C:24]2=4)[NH:19][CH:18]=3)[N:14]([CH2:28][CH2:29][CH3:30])[CH2:13]1

Komponenten

5

Edukt 2

HCID 139664588alpha-Benzyloxycarbonylamino-6-n-propylergolineHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 134688038alpha-Amino-6-n-propylergoline

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

12 g (ca 30 mM) of 8α-benzyloxycarbonylamino)-6-n-propylergoline obtained from step (d) and 1.5 g palladium on charcoal (10% by weight) in 500 ml ethanol are hydrogenated at normal pressure until hydrogen uptake ceases. The mixture is filtered and concentrated. This resultant heading compound is crystallised from methanol.

Aufarbeitung

  1. filtrationThe mixture is filtered
  2. concentrationconcentrated
  3. customis crystallised from methanol

Quellen und Nachweise

ORD-Eintrag
ord-1847d07e81a74fdd8f8adb629f105173
Quelldatensatz
uspto-grants-1988_08
Patentnummer
US04764517

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