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Potassium Iodide → 7-(2-Propyl-3,4-dichlorophenoxy)heptanoic acid

HRID 34978
Notizen
Druckvorschau

Reaktionsgleichung

Reaktionsgleichung von HRID 34978
[CH2:1]([C:4]1[C:9]([Cl:10])=[C:8]([Cl:11])[CH:7]=[CH:6][C:5]=1[OH:12])[CH2:2][CH3:3].Br[CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][C:20]([OH:22])=[O:21].C(=O)([O-])[O-].[K+].[K+].[I-].[K+]>C(C(C)=O)C>[CH2:1]([C:4]1[C:9]([Cl:10])=[C:8]([Cl:11])[CH:7]=[CH:6][C:5]=1[O:12][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][C:20]([OH:22])=[O:21])[CH2:2][CH3:3]
KomponentenVersuchsvorschriftAufarbeitungQuellen und NachweiseNotizen zur Reaktion

Komponenten

6

Edukt 4

HCID 4875Potassium IodideHCID 11430Potassium CarbonateHCID 1217237-Bromoheptanoic acidHCID 6003603,4-Dichloro-2-propylphenol

Produkt 1

HCID 212972877-(2-Propyl-3,4-dichlorophenoxy)heptanoic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6569
Methyl Ethyl Ketone
Lösungsmittel

Versuchsvorschrift

A solution of 3.09 g. of 2-propyl-3,4-dichlorophenol, 3.1 g. of 7-bromoheptanoic acid, 3.1 g. of potassium carbonate, and 2.0 g. of potassium iodide in 50 ml. of methyl ethyl ketone was heated at reflux overnight. The reaction mixture was cooled to room temperature and evaporated in vacuo. Ethyl acetate and water were added to the residue and the layers were separated. Fresh water was added to the organic layer, the pH was adjusted to 2.0 with acid, and the layers were separated. The organic layer was washed with a saturated sodium chloride solution, filtered through sodium sulfate, and evaporated to dryness to give 4.68 g. of the desired title product.

Aufarbeitung

  1. temperatureat reflux overnight
  2. customevaporated in vacuo
  3. additionEthyl acetate and water were added to the residue
  4. customthe layers were separated
  5. additionFresh water was added to the organic layer
  6. customthe layers were separated
  7. washThe organic layer was washed with a saturated sodium chloride solution
  8. filtrationfiltered through sodium sulfate
  9. customevaporated to dryness
  10. customto give 4.68 g

Quellen und Nachweise

ORD-Eintrag
ord-310b7c0479814ee9878d944c0f91516a
Quelldatensatz
uspto-grants-1988_08
DOI
10.6084/m9.figshare.5104873.v1
Patentnummer
US04764521

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