Water → 2-(2-Quinolylmethoxy)-5-pyridylmethanol

HRID 349975

Reaktionsgleichung

Reaktionsgleichung von HRID 349975
[H-].[Na+].[N:3]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[CH:6]=[CH:5][C:4]=1[CH2:13][OH:14].Cl[C:16]1[N:21]=[CH:20][C:19]([C:22](OC)=[O:23])=[CH:18][CH:17]=1.O>CN(C)C=O>[N:3]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[CH:6]=[CH:5][C:4]=1[CH2:13][O:14][C:16]1[CH:17]=[CH:18][C:19]([CH2:22][OH:23])=[CH:20][N:21]=1

Komponenten

6

Edukt 4

HCID 962WaterHCID 24758Sodium hydrideHCID 731962-QuinolinemethanolHCID 254249Methyl 6-chloropyridine-3-carboxylate

Produkt 1

HCID 224135802-(2-Quinolylmethoxy)-5-pyridylmethanolAusbeute 50,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

Sodium hydride (60%, oily, 1.58 g) was added to a solution of 2-quinolylmethanol (6.29 g) and methyl 6-chloro-3-pyridinecarboxylate (6.78 g) in N,N-dimethylformamide (100 ml) at 0° C., and the mixture was stirred for 1 hour. The reaction mixture was poured into water, which was extracted with ethyl acetate. The ethyl acetate layer was washed with saturated aqueous sodium chloride solution, dried (MgSO4), and concentrated. Lithium aluminium hydride (1.50 g) was added to a solution of the residue in tetrahydrofuran (150 ml) at 0° C., which was stirred at room temperature for 10 minutes. Sodium sulfate decahydrate (12.7 g) was added to the reaction mixture, which was stirred at room temperature for 1 hour. The precipitate was removed by filtration, and the filtrate was concentrated. The residue was subjected to silica gel column chromatography to obtain 2-(2-quinolylmethoxy)-5-pyridylmethanol (5.31 g, yield 50%) as colorless crystals from the fraction eluted with ethyl acetate. This was recrystallized from ethyl acetate-hexane. Melting point: 124–125° C.

Aufarbeitung

  1. extractionwas extracted with ethyl acetate
  2. washThe ethyl acetate layer was washed with saturated aqueous sodium chloride solution
  3. dry with materialdried (MgSO4)
  4. concentrationconcentrated
  5. additionLithium aluminium hydride (1.50 g) was added to a solution of the residue in tetrahydrofuran (150 ml) at 0° C.
  6. stirringwhich was stirred at room temperature for 10 minutes
  7. additionSodium sulfate decahydrate (12.7 g) was added to the reaction mixture, which
  8. stirringwas stirred at room temperature for 1 hour
  9. customThe precipitate was removed by filtration
  10. concentrationthe filtrate was concentrated

Quellen und Nachweise

ORD-Eintrag
ord-6411bf0a3b694b63b90316b29ea63965
Quelldatensatz
uspto-grants-2007_02
Patentnummer
US07179823B1

Verknüpfte Notizen

Wird geladen…