Hydrazine → 3-Chloro-10,11-dihydro-10-(4-aminobenzoyl)-5H-pyrrolo[2,1-c][1,4]benzodiazepine

HRID 3503Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 3503
[Cl:1][C:2]1[N:11]2[C:5]([CH2:6][N:7]([C:16](=[O:27])[C:17]3[CH:22]=[CH:21][C:20]([NH:23][N+]([O-])=O)=[CH:19][CH:18]=3)[C:8]3[CH:15]=[CH:14][CH:13]=[CH:12][C:9]=3[CH2:10]2)=[CH:4][CH:3]=1.NN>[Pd].C(O)C>[Cl:1][C:2]1[N:11]2[C:5]([CH2:6][N:7]([C:16](=[O:27])[C:17]3[CH:18]=[CH:19][C:20]([NH2:23])=[CH:21][CH:22]=3)[C:8]3[CH:15]=[CH:14][CH:13]=[CH:12][C:9]=3[CH2:10]2)=[CH:4][CH:3]=1

Komponenten

5

Edukt 2

HCID 9321HydrazineHCID 218369643-chloro-10,11-di-hydro-10-(4-nitroaminobenzoyl)-5H-pyrrolo[2,1-c][1,4]benzodiazepine

Produkt 1

HCID 218370993-Chloro-10,11-dihydro-10-(4-aminobenzoyl)-5H-pyrrolo[2,1-c][1,4]benzodiazepine

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

A mixture of 1 mmol of 3-chloro-10,11-dihydro-10-(4-nitroaminobenzoyl)-5H-pyrrolo[2,1-c][1,4]benzodiazepine, 2.5 mmol of anhydrous hydrazine, 50 mg of palladium on carbon and 10 ml of ethyl alcohol is refluxed for 1.5 hours. The mixture is filtered through diatomaceous earth and the filtrate concentrated to dryness to give the desired product as a solid.

Aufarbeitung

  1. temperatureis refluxed for 1.5 hours
  2. filtrationThe mixture is filtered through diatomaceous earth
  3. concentrationthe filtrate concentrated to dryness

Quellen und Nachweise

ORD-Eintrag
ord-9414b7fc6c2b4a35b0deb6bc71152998
Quelldatensatz
uspto-grants-1998_03
Patentnummer
US05733905

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