Piperidine → Methyl 3-(piperidin-1-ylmethyl)benzoate

HRID 35037

Reaktionsgleichung

Reaktionsgleichung von HRID 35037
[NH:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.Br[CH2:8][C:9]1[CH:10]=[C:11]([CH:16]=[CH:17][CH:18]=1)[C:12]([O:14][CH3:15])=[O:13]>C1(C)C=CC=CC=1>[N:1]1([CH2:8][C:9]2[CH:10]=[C:11]([CH:16]=[CH:17][CH:18]=2)[C:12]([O:14][CH3:15])=[O:13])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Komponenten

4

Edukt 2

HCID 8082PiperidineHCID 517981Methyl 3-(bromomethyl)benzoate

Produkt 1

HCID 7162043Methyl 3-(piperidin-1-ylmethyl)benzoate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1140TolueneLösungsmittel

Versuchsvorschrift

A mixture of piperidine (25 ml) and 3-(bromomethyl)benzoic acid, methyl ester (20 g) in toluene (600 ml) was stirred at room temperature for 4 h. The white preciptiate was removed by filtration and the filtrate was distilled to give the title compound as a colourless oil (17.56 g) b.p. 110° (10-1 mm). TLC silica; ether; Rf 0.7.

Aufarbeitung

  1. customThe white preciptiate was removed by filtration
  2. distillationthe filtrate was distilled

Quellen und Nachweise

ORD-Eintrag
ord-d2db7d61cdb94d9a851edbff15c6518d
Quelldatensatz
uspto-grants-1988_08
Patentnummer
US04764612

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