Hydrochloric Acid → HCID 178520398, Verbindung

HRID 350616

Reaktionsgleichung

Reaktionsgleichung von HRID 350616
[C:1]([CH2:3][C:4]([NH:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)=[O:5])#[N:2].C([Sn]([N:26]=[N+:27]=[N-:28])(CCCC)CCCC)CCC.Cl>C1(C)C=CC=CC=1.CCOCC>[NH:26]1[C:1]([CH2:3][C:4]([NH:6][C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)=[O:5])=[N:2][N:28]=[N:27]1

Komponenten

6

Edukt 3

HCID 313Hydrochloric AcidHCID 69296Acetamide, 2-cyano-N-phenyl-HCID 4984872Tributyltin azide

Produkt 1

HCID 178520398HCID 178520398, VerbindungAusbeute 90,3 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 1140TolueneLösungsmittelHCID 3283Diethyl EtherLösungsmittel

Versuchsvorschrift

A solution of 2-cyano-acetanilide (0.801 g, 5.0 mmol) and tri-n-butyltin azide (2.05 mL, 7.5 mmol) in anhydrous toluene (10 mL) was heated at reflux for 48 hrs. The mixture was allowed to cool to room temperature and treated with 2.0 N HCl in Et2O (5.0 mL). The resulting precipate was collected by suction, washed with hexane and dried in vacuo to give 2-(1H-tetrazol-5-yl)acetanilide (0.917 g, 90%) as a white solid.

Aufarbeitung

  1. temperatureat reflux for 48 hrs
  2. customThe resulting precipate was collected by suction
  3. washwashed with hexane
  4. customdried in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-c70a5eba16b7425b8003797554719346
Quelldatensatz
uspto-grants-2007_02
Patentnummer
US07183260B2

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