Propyl mercaptan → Methyl 3-[4-(4-chlorophenyl)-2-(1-propylsulfanyl)-5-oxazolyl]propionate

HRID 350731Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 350731
[CH2:1]([SH:4])[CH2:2][CH3:3].C[O-].[Na+].Cl[C:9]1[O:10][C:11]([CH2:21][CH2:22][C:23]([O:25][CH3:26])=[O:24])=[C:12]([C:14]2[CH:19]=[CH:18][C:17]([Cl:20])=[CH:16][CH:15]=2)[N:13]=1>CO>[Cl:20][C:17]1[CH:16]=[CH:15][C:14]([C:12]2[N:13]=[C:9]([S:4][CH2:1][CH2:2][CH3:3])[O:10][C:11]=2[CH2:21][CH2:22][C:23]([O:25][CH3:26])=[O:24])=[CH:19][CH:18]=1

Komponenten

5

Edukt 3

HCID 7848Propyl mercaptanHCID 10942334Sodium MethoxideHCID 10990225Methyl 3-[2-chloro-4-(4-chlorophenyl)-5-oxazolyl]propionate

Produkt 1

HCID 23061674Methyl 3-[4-(4-chlorophenyl)-2-(1-propylsulfanyl)-5-oxazolyl]propionate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

To a solution of 1-propylmercaptan (0.54 mL) in methanol (20 mL) was added sodium methoxide (1.1 g) and then methyl 3-[2-chloro-4-(4-chlorophenyl)-5-oxazolyl]propionate (1.5 g) was added. The mixture was stirred with heating under reflux for 30 min. The reaction mixture was concentrated, diluted with water, and extracted with ethyl acetate. The organic layer was washed successively with water and saturated brine, dried over anhydrous magnesium sulfate and concentrated. The residue was subjected to silica gel column chromatography, and methyl 3-[4-(4-chlorophenyl)-2-(1-propylsulfanyl)-5-oxazolyl]propionate was obtained from a fraction eluted with hexane-acetone (9:1, volume ratio). 2N Aqueous sodium hydroxide solution (5 mL) and methanol (15 mL) were added to this ester form, and the mixture was stirred at room temperature for 1 hr. The reaction mixture was diluted with water and acidified with 2N aqueous hydrochloric acid solution. The precipitated crystals were collected by filtration and recrystallized from isopropyl ether to give 3-[4-(4-chlorophenyl)-2-(1-propylsulfanyl)-5-oxazolyl]propionic acid (1.0 g, yield 63%) as colorless prism crystals. melting point: 128–129° C.

Aufarbeitung

  1. temperaturewith heating
  2. temperatureunder reflux for 30 min
  3. concentrationThe reaction mixture was concentrated
  4. additiondiluted with water
  5. extractionextracted with ethyl acetate
  6. washThe organic layer was washed successively with water and saturated brine
  7. dry with materialdried over anhydrous magnesium sulfate
  8. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-d9a59e1fad4a4d1a8f297a235cf8a134
Quelldatensatz
uspto-grants-2007_02
Patentnummer
US07183276B2

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