Diethyl Ether → HCID 10084623, Verbindung

HRID 351110Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 351110
[C:1](Cl)(=[O:3])[CH3:2].[NH2:5][C:6]1[S:10][C:9]2[C:11]3[C:16]([CH2:17][C:8]=2[C:7]=1[C:18]([NH2:20])=[O:19])=[CH:15][CH:14]=[CH:13][CH:12]=3.C(OCC)C>N1C=CC=CC=1>[C:1]([NH:5][C:6]1[S:10][C:9]2[C:11]3[C:16]([CH2:17][C:8]=2[C:7]=1[C:18]([NH2:20])=[O:19])=[CH:15][CH:14]=[CH:13][CH:12]=3)(=[O:3])[CH3:2]

Komponenten

5

Edukt 3

HCID 3283Diethyl EtherHCID 6367Acetyl chlorideHCID 10220223HCID 10220223, Verbindung

Produkt 1

HCID 10084623HCID 10084623, VerbindungAusbeute 87 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1049PyridineLösungsmittel

Versuchsvorschrift

Acetyl chloride (0.039 g, 0.5 mmol) was added dropwise to a stirred solution of 2-amino-4H-indeno[1,2-b]thiophene-3-carboxylic acid amide(0.115 g, 0.5 mmol) in dry pyridine (3 mL) at room temperature. The resulting reaction mixture was stirred under nitrogen for 2 h. Ethyl ether (20 mL) was then added to the reaction mixture. The reaction mixture was allowed to stir an additional 10 minutes. The reaction mixture was then filtered, washed with excess ethyl ether, air dried to give the title compound as light brown solid (0.082 g, 0.435 mmol, 60.3% yield). ESMS m/z: 273 [M+H]+.

Aufarbeitung

  1. customThe resulting reaction mixture
  2. stirringto stir an additional 10 minutes
  3. filtrationThe reaction mixture was then filtered
  4. washwashed with excess ethyl ether, air
  5. customdried

Quellen und Nachweise

ORD-Eintrag
ord-73fe2dbbfcfe48d5b116748357374bf3
Quelldatensatz
uspto-grants-2007_02
Patentnummer
US07183311B2

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