Ethanol → HCID 23022412, Verbindung

HRID 351347

Reaktionsgleichung

Reaktionsgleichung von HRID 351347
Br[CH2:2][CH2:3][CH2:4][CH2:5][F:6].[F:7][C:8]1[CH:16]=[C:15]([OH:17])[CH:14]=[CH:13][C:9]=1[C:10]([OH:12])=[O:11].C(O)C.[OH-].[K+]>O>[F:7][C:8]1[CH:16]=[C:15]([O:17][CH2:2][CH2:3][CH2:4][CH2:5][F:6])[CH:14]=[CH:13][C:9]=1[C:10]([OH:12])=[O:11]

Komponenten

6

Edukt 4

HCID 702EthanolHCID 100221-Bromo-4-fluorobutaneHCID 14797Potassium HydroxideHCID 27833982-Fluoro-4-hydroxybenzoic Acid

Produkt 1

HCID 23022412HCID 23022412, VerbindungAusbeute 39,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Reaktionsbedingungen

Temperatur
80 °C

Versuchsvorschrift

1-Bromo-4-fluorobutane (3.57 g, 23.1 mmol) was added dropwise to a mixture of 2-fluoro-4-hydroxybenzoic acid (3.00 g, 19.2 mmol), ethanol (11.5 ml) and water (2.3 ml), potassium hydroxide (2.37 g, 42.3 mmol) at 80° C., and the mixture was stirred at 80° C. for 17 hrs. The solvent was evaporated under reduced pressure. The residue was dissolved in water and the solution was acidified by adding 1N hydrochloric acid. The insoluble materials were filtered off and dried to give the title compound (1.73 g) as a pale-brown powder.

Aufarbeitung

  1. customThe solvent was evaporated under reduced pressure
  2. dissolutionThe residue was dissolved in water
  3. additionby adding 1N hydrochloric acid
  4. filtrationThe insoluble materials were filtered off
  5. customdried

Quellen und Nachweise

ORD-Eintrag
ord-a90d447d5d524a98a661fb371990aede
Quelldatensatz
uspto-grants-2007_02
Patentnummer
US07183415B2

Verknüpfte Notizen

Wird geladen…