Potassium Carbonate → Diethyl-2-[4'-(4"-cyano-phenoxy)-phenoxy]-propionyl-malonate

HRID 35146

Reaktionsgleichung

Reaktionsgleichung von HRID 35146
[C:1]([C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1O)#[N:2].[CH2:10]([O:12][C:13](=[O:32])[CH:14]([C:20](=[O:31])[CH:21]([O:23][C:24]1[CH:29]=[CH:28][C:27](F)=[CH:26][CH:25]=1)[CH3:22])[C:15]([O:17][CH2:18][CH3:19])=[O:16])[CH3:11].C(=O)([O-])[O-:34].[K+].[K+]>CS(C)=O>[CH2:10]([O:12][C:13](=[O:32])[CH:14]([C:20](=[O:31])[CH:21]([O:23][C:24]1[CH:29]=[CH:28][C:27]([O:34][C:6]2[CH:7]=[CH:8][C:3]([C:1]#[N:2])=[CH:4][CH:5]=2)=[CH:26][CH:25]=1)[CH3:22])[C:15]([O:17][CH2:18][CH3:19])=[O:16])[CH3:11]

Komponenten

5

Edukt 3

HCID 11430Potassium CarbonateHCID 119072-HydroxybenzonitrileHCID 23037018Diethyl-2-(4'-fluoro-phenoxy)-propionyl-malonate

Produkt 1

HCID 21295006Diethyl-2-[4'-(4"-cyano-phenoxy)-phenoxy]-propionyl-malonateAusbeute 86 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 679Dimethyl SulfoxideLösungsmittel

Reaktionsbedingungen

Temperatur
60 °C

Versuchsvorschrift

11.9 g of cyano-phenol and 32.6 g of diethyl-2-(4'-fluoro-phenoxy)-propionyl-malonate are dissolved in 150 ml of dimethyl sulfoxide, whereupon 13.8 g of potassium carbonate are added and the reaction mixture is stirred at 60° C. for 6 hours. The reaction mixture is filtered and the filtrate is evaporated. Thus 36 g of the desired compound are obtained, yield 86%.

Aufarbeitung

  1. additionare added
  2. filtrationThe reaction mixture is filtered
  3. customthe filtrate is evaporated

Quellen und Nachweise

ORD-Eintrag
ord-39eba38794a340b28f97b842753e7fc2
Quelldatensatz
uspto-grants-1988_08
Patentnummer
US04765825

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