Water → HCID 22713205, Verbindung

HRID 351531Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 351531
[H-].[Na+].[C:3]([N:6]1[CH2:11][CH2:10][N:9]([C:12]2[CH:17]=[CH:16][C:15]([OH:18])=[CH:14][CH:13]=2)[CH2:8][CH2:7]1)(=[O:5])[CH3:4].Br[CH:20]1[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]1.O>CN(C)C=O.C(OCC)(=O)C>[C:3]([N:6]1[CH2:7][CH2:8][N:9]([C:12]2[CH:17]=[CH:16][C:15]([O:18][CH:20]3[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]3)=[CH:14][CH:13]=2)[CH2:10][CH2:11]1)(=[O:5])[CH3:4]

Komponenten

7

Edukt 4

HCID 962WaterHCID 7960Cyclohexyl bromideHCID 24758Sodium hydrideHCID 7124411-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone

Produkt 1

HCID 22713205HCID 22713205, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 6228DimethylformamideLösungsmittelHCID 8857Ethyl AcetateLösungsmittel

Reaktionsbedingungen

Temperatur
100 °C

Versuchsvorschrift

To a suspension of sodium hydride (60% suspension in mineral oil) (1.18 g) in dimethylformamide (25 ml) was added 1-acetyl-4-(4-hydroxyphenyl)piperazine (5 g) and bromocyclohexane (5.59 ml) and stirred for 1 hour at 100° C. The reaction mixture was added to a mixture of water and ethyl acetate. The organic layer was taken and dried over magnesium sulfate. The magnesium sulfate was filtered off, and the filtrate was evaporated under reduced pressure to give 1-acetyl-4-(4-cyclohexyloxyphenyl)piperazine (0.92 g).

Aufarbeitung

  1. dry with materialdried over magnesium sulfate
  2. filtrationThe magnesium sulfate was filtered off
  3. customthe filtrate was evaporated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-eb52e27e486347f98cfeb356361f011b
Quelldatensatz
uspto-grants-2004_06
Patentnummer
US06743776B2

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