Water → 1-Acetyl-4-(4-hexyloxyphenyl)piperazine

HRID 351546

Reaktionsgleichung

Reaktionsgleichung von HRID 351546
[C:1]([N:4]1[CH2:9][CH2:8][N:7]([C:10]2[CH:15]=[CH:14][C:13]([OH:16])=[CH:12][CH:11]=2)[CH2:6][CH2:5]1)(=[O:3])[CH3:2].C(=O)(O)[O-].[K+].Br[CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH3:28].O>CS(C)=O.C(OCC)(=O)C>[C:1]([N:4]1[CH2:5][CH2:6][N:7]([C:10]2[CH:15]=[CH:14][C:13]([O:16][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH3:28])=[CH:12][CH:11]=2)[CH2:8][CH2:9]1)(=[O:3])[CH3:2]

Komponenten

7

Edukt 4

HCID 962WaterHCID 81011-BromohexaneHCID 516893Potassium BicarbonateHCID 7124411-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone

Produkt 1

HCID 227132431-Acetyl-4-(4-hexyloxyphenyl)piperazine

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 679Dimethyl SulfoxideLösungsmittelHCID 8857Ethyl AcetateLösungsmittel

Reaktionsbedingungen

Temperatur
80 °C

Versuchsvorschrift

To a suspension of 1-acetyl-4-(4-hydroxyphenyl) piperazine (20 g) and potassium bicarbonate (12.55 g) in dimethylsulfoxide (200 ml) was added 1-bromohexane (19.12 ml) and stirred for 24 hours at 80° C. The reaction mixture was added to a mixture of water and ethyl acetate. The organic layer was taken and dried over is magnesium sulfate. The magnesium sulfate was filtered off, and the filtrate was evaporated under reduced pressure to give 1-acetyl-4-(4-hexyloxyphenyl)piperazine (14.5 g).

Aufarbeitung

  1. customdried
  2. filtrationThe magnesium sulfate was filtered off
  3. customthe filtrate was evaporated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-55960f6b25f8486b9db79f648a9dc4ae
Quelldatensatz
uspto-grants-2004_06
Patentnummer
US06743776B2

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