Sodium Carbonate → HCID 15612244, Verbindung

HRID 35194

Reaktionsgleichung

Reaktionsgleichung von HRID 35194
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([CH2:7][C:8]2[CH:17]=[CH:16][C:15]3[C:10](=[CH:11][CH:12]=[C:13]([C:18]4([CH3:23])OCC[O:19]4)[CH:14]=3)[CH:9]=2)[CH:2]=1.C(=O)([O-])[O-].[Na+].[Na+]>Cl>[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([CH2:7][C:8]2[CH:17]=[CH:16][C:15]3[C:10](=[CH:11][CH:12]=[C:13]([C:18](=[O:19])[CH3:23])[CH:14]=3)[CH:9]=2)[CH:2]=1

Komponenten

4

Edukt 2

HCID 10340Sodium CarbonateHCID 156122432-(3-Pyridylmethyl)-6-(2-methyl-1,3-dioxolan-2-yl)naphthalene

Produkt 1

HCID 15612244HCID 15612244, VerbindungAusbeute 101,3 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 313Hydrochloric AcidLösungsmittel

Versuchsvorschrift

A solution of 150 mg of 2-(3-pyridylmethyl)-6-(2-methyl-1,3-dioxolan-2-yl)naphthalene in 15 ml of 1N hydrochloric acid was allowed to stand for 3 hours at room temperature. The solution was neutralized with sodium carbonate and extracted with methylene chloride. The organic layer was dried over sodium sulfate and the solvent removed under reduced pressure to give 130 mg of 2-(3-pyridylmethyl)-6-acetylnaphthalene as an oil.

Aufarbeitung

  1. extractionextracted with methylene chloride
  2. dry with materialThe organic layer was dried over sodium sulfate
  3. customthe solvent removed under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-d087129627ad4ec4a8be14aecff590ba
Quelldatensatz
uspto-grants-1988_08
Patentnummer
US04766127

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