4-Methylmorpholine → 4-Chloro-2-methoxybenzaldehyde

HRID 352835

Reaktionsgleichung

Reaktionsgleichung von HRID 352835
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][OH:9])=[C:4]([O:10][CH3:11])[CH:3]=1.CN1CCOCC1>C(Cl)Cl.[Ru]([O-])(=O)(=O)=O.C([N+](CCC)(CCC)CCC)CC>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]=[O:9])=[C:4]([O:10][CH3:11])[CH:3]=1

Komponenten

5

Edukt 2

HCID 79724-MethylmorpholineHCID 35493934 Chloro-2-methoxybenzyl alcohol

Produkt 1

HCID 138651154-Chloro-2-methoxybenzaldehyde

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 178419074HCID 178419074, VerbindungKatalysatorHCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

In methylene chloride (80 ml) was dissolved (4-chloro-2-methoxyphenyl)methanol (3.69 g). Under ice cooling, molecular sieve 4A (4.57 g), N-methylmorpholine (2.81 g) and tetra-n-propylammonium perruthenate (420 mg) were added to the resulting solution, followed by stirring at room temperature for 2.5 hours. The reaction mixture was distilled under reduced pressure. The residue was subjected to chromatography on a silica gel column (hexane:ethyl acetate=9:1), whereby the title compound (3.07 g) was obtained as pale yellow oil.

Aufarbeitung

  1. distillationThe reaction mixture was distilled under reduced pressure
  2. customwas obtained as pale yellow oil

Quellen und Nachweise

ORD-Eintrag
ord-ad5fea9e0b5f4ceb8a3ddf1d9c72e567
Quelldatensatz
uspto-grants-2004_06
Patentnummer
US06747023B1

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