Calcium hypochlorite → HCID 22708344, Verbindung

HRID 353246

Reaktionsgleichung

Reaktionsgleichung von HRID 353246
[Cl:1][O-].[Ca+2].Cl[O-].[F:6][C:7]([F:21])([F:20])[O:8][C:9]1[CH:10]=[CH:11][CH:12]=[C:13]2[C:18]=1[O:17][CH2:16][CH2:15][C:14]2=[O:19]>O.C(O)(=O)C.C(#N)C.O>[Cl:1][C:11]1[CH:12]=[C:13]2[C:18](=[C:9]([O:8][C:7]([F:6])([F:20])[F:21])[CH:10]=1)[O:17][CH2:16][CH2:15][C:14]2=[O:19]

Komponenten

6

Edukt 2

HCID 24504Calcium hypochloriteHCID 22708350HCID 22708350, Verbindung

Produkt 1

HCID 22708344HCID 22708344, VerbindungAusbeute 87 %

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 962WaterLösungsmittelHCID 6342AcetonitrileLösungsmittelHCID 21899381Acetic acid--water (1/1)Lösungsmittel

Versuchsvorschrift

To a solution of calcium hypochlorite (15.4 g, 72.4 mmol) in water:acetic acid (65:5) was added a solution of 8-trifluoromethoxychroman-4-one (4.2 g, 18.1 mmol; from step (iv) above) in acetonitrile (20 mL), whereafter the reaction mixture was stirred overnight. The mixture was diluted with water and extracted with ether (3 times) and EtOAc (once). The combined organic layer was washed with water, dried (Na2SO4) and evaporated, yielding 4.2 g (87%) of the sub-tide compound.

Aufarbeitung

  1. extractionextracted with ether (3 times) and EtOAc (once)
  2. washThe combined organic layer was washed with water
  3. dry with materialdried (Na2SO4)
  4. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-043020b1396d4c3b960816fe83620a9d
Quelldatensatz
uspto-grants-2004_06
Patentnummer
US06750243B1

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