Bromine → 3-Fluoro-4-methoxyphenacyl bromide

HRID 353727

Reaktionsgleichung

Reaktionsgleichung von HRID 353727
[F:1][C:2]1[CH:3]=[C:4]([C:10](=[O:12])[CH3:11])[CH:5]=[CH:6][C:7]=1[O:8][CH3:9].[Br:13]Br>O1CCOCC1>[Br:13][CH2:11][C:10]([C:4]1[CH:5]=[CH:6][C:7]([O:8][CH3:9])=[C:2]([F:1])[CH:3]=1)=[O:12]

Komponenten

4

Edukt 2

HCID 24408BromineHCID 968281-(3-Fluoro-4-methoxyphenyl)ethan-1-one

Produkt 1

HCID 70618463-Fluoro-4-methoxyphenacyl bromideAusbeute 63 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel2×

Versuchsvorschrift

To a solution of 3′-fluoro-4′-methoxyacetophenone (1 g, 5.9 mmol) (Aldrich) in dioxane (10 mL) was added dropwise a solution of bromine (1.13 g, 7.1 mmol) in dioxane (30 mL). After stirring for 10 minutes, the mixture was concentrated in vacuo and the residue was purified by flash chromatography, with 10:4 hexanes/dichloromethane as an eluant, to provide 2-bromo-1-(3-fluoro-4-methoxyphenyl)ethanone as a white powder (910 mg, 63% yield).

Aufarbeitung

  1. concentrationthe mixture was concentrated in vacuo
  2. customthe residue was purified by flash chromatography, with 10:4 hexanes/dichloromethane as an eluant

Quellen und Nachweise

ORD-Eintrag
ord-9b6db527d6d14d4b8d3d3e03388a5698
Quelldatensatz
uspto-grants-2004_06
Patentnummer
US06756374B2

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