Bromine → 2-Bromo-1-(3,5-difluorophenyl)ethanone

HRID 353728

Reaktionsgleichung

Reaktionsgleichung von HRID 353728
[F:1][C:2]1[CH:3]=[C:4]([C:9](=[O:11])[CH3:10])[CH:5]=[C:6]([F:8])[CH:7]=1.[Br:12]Br>O1CCOCC1>[Br:12][CH2:10][C:9]([C:4]1[CH:3]=[C:2]([F:1])[CH:7]=[C:6]([F:8])[CH:5]=1)=[O:11]

Komponenten

4

Edukt 2

HCID 24408BromineHCID 5185963',5'-Difluoroacetophenone

Produkt 1

HCID 27783312-Bromo-1-(3,5-difluorophenyl)ethanoneAusbeute 64,3 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel2×

Versuchsvorschrift

To a solution of 3′,5′-difluoroacetophenone (3 g, 19.2 mmol) (Lancaster Synthesis) in dioxane (30 mL) was added dropwise a solution of bromine (3.67 g, 23 mmol) in dioxane (75 mL). After stirring for 10 minutes, the mixture was concentrated in vacuo and the residue was purified by flash chromatography, with 10:2 hexanes/dichloromethane as an eluant, to provide 2-bromo-1-(3,5-difluorophenyl)ethanone as a colorless oil (2.9 g, 64% yield).

Aufarbeitung

  1. concentrationthe mixture was concentrated in vacuo
  2. customthe residue was purified by flash chromatography, with 10:2 hexanes/dichloromethane as an eluant

Quellen und Nachweise

ORD-Eintrag
ord-0983911438fc4665b760dfdbb7ac7f37
Quelldatensatz
uspto-grants-2004_06
Patentnummer
US06756374B2

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