Triethylorthoaceate → N1-[3-(2-methyl-1H-imidazo[4,5-c]quinolin-1-yl)propyl]benzamide

HRID 353841

Reaktionsgleichung

Reaktionsgleichung von HRID 353841
[N+:1]([C:4]1[CH:5]=[N:6][C:7]2[C:12]([C:13]=1[NH:14][CH2:15][CH2:16][CH2:17][NH:18][C:19](=[O:26])[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)=[CH:11][CH:10]=[CH:9][CH:8]=2)([O-])=O.[CH2:27](C(CC)(CC)C([O-])([O-])[O-])[CH3:28]>>[CH3:27][C:28]1[N:14]([CH2:15][CH2:16][CH2:17][NH:18][C:19](=[O:26])[C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[C:13]2[C:12]3[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=3[N:6]=[CH:5][C:4]=2[N:1]=1

Komponenten

3

Edukt 2

HCID 21875354TriethylorthoaceateHCID 23512704N1-{3-[(3-nitroquinolin-4-yl)amino]propyl}benzamide

Produkt 1

HCID 23512664N1-[3-(2-methyl-1H-imidazo[4,5-c]quinolin-1-yl)propyl]benzamide

Versuchsvorschrift

Using the general method of Example 11 Part C, N1-{3-[(3-nitroquinolin-4-yl)amino]propyl}benzamide (2.0 g, 5.7 mmol) was reduced to the diamine and then reacted with triethylorthoacetate to provide 0.74 g of N1-[3-(2-methyl-1H-imidazo[4,5-c]quinolin-1-yl)propyl]benzamide as a sticky dark yellow solid.

Quellen und Nachweise

ORD-Eintrag
ord-0f6a1ca1f4e4404a9c5b5a91220b0345
Quelldatensatz
uspto-grants-2004_06
Patentnummer
US06756382B2

Verknüpfte Notizen

Wird geladen…