Water → Monochloromethyl 2-trifluoromethyl-3,3,3-trifluoropropanoate

HRID 35386

Reaktionsgleichung

Reaktionsgleichung von HRID 35386
[Cl:1][CH2:2][O:3][C:4](F)(F)[CH:5]([C:10]([F:13])([F:12])[F:11])[C:6]([F:9])([F:8])[F:7].O.S(=O)(=O)(O)[OH:18]>>[F:7][C:6]([F:9])([F:8])[CH:5]([C:10]([F:13])([F:12])[F:11])[C:4]([O:3][CH2:2][Cl:1])=[O:18]

Komponenten

4

Edukt 3

HCID 962WaterHCID 1118Sulfuric AcidHCID 138276951-Chloromethoxy-1,1-difluoro-2-trifluoromethyl-3,3,3-trifluoropropane

Produkt 1

HCID 13954659Monochloromethyl 2-trifluoromethyl-3,3,3-trifluoropropanoateAusbeute 101,1 %

Versuchsvorschrift

In a four necked 1 liter flask equipped with a thermometer, a condenser and a stirrer, 1-chloromethoxy-1,1-difluoro-2-trifluoromethyl-3,3,3-trifluoropropane (276.6 g, 1.04 mol) and water (18.7 g, 1.04 mol) were charged, and concentrated sulfuric acid (74.8 g, 0.76 mol) was dropwise added thereto while stirring The reaction was continued at 110° C. for 20 hours. Then, the reaction mixture was distilled to give monochloromethyl 2-trifluoromethyl-3,3,3-trifluoropropanoate (187.8 g).

Aufarbeitung

  1. additionwere charged
  2. distillationThen, the reaction mixture was distilled

Quellen und Nachweise

ORD-Eintrag
ord-e4070553ddc946cb8b5dbbc6afa5647f
Quelldatensatz
uspto-grants-1988_08
Patentnummer
US04766238

Verknüpfte Notizen

Wird geladen…