Sulfuric Acid → 2-Chloro-N-[(6-hydroxy-2,3-dihydro-1H-inden-5-yl)methyl]acetamide

HRID 35412

Reaktionsgleichung

Reaktionsgleichung von HRID 35412
[OH:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[CH2:7][CH2:6][CH2:5]2.[Cl:11][CH2:12][C:13]([NH:15][CH2:16]O)=[O:14].S(=O)(=O)(O)O>C(O)(=O)C>[Cl:11][CH2:12][C:13]([NH:15][CH2:16][C:10]1[CH:9]=[C:8]2[C:4]([CH2:5][CH2:6][CH2:7]2)=[CH:3][C:2]=1[OH:1])=[O:14]

Komponenten

5

Edukt 3

HCID 1118Sulfuric AcidHCID 151185-IndanolHCID 62466N-Methylol-alpha-chloroacetamide

Produkt 1

HCID 212969152-Chloro-N-[(6-hydroxy-2,3-dihydro-1H-inden-5-yl)methyl]acetamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel

Versuchsvorschrift

134 g (1 mole) of 5-hydroxyindane and 100 g (0.81 mole) of 2-chloro-N-hydroxymethylacetamide are suspended in 300 ml of glacial acetic acid, and 10 ml of concentrated sulfuric acid are added. The mixture is stirred for 30 minutes at room temperature and is poured into ice water. The product is filtered off with suction and recrystallized from methanol.

Aufarbeitung

  1. filtrationThe product is filtered off with suction
  2. customrecrystallized from methanol

Quellen und Nachweise

ORD-Eintrag
ord-9f24ddb28e444a7a9f35cd26d6f49873
Quelldatensatz
uspto-grants-1988_08
Patentnummer
US04766241

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