Methanol → Methyl 2-(3-chlorophenyl)acetate

Temperatur

80 °C

To a stirred solution of 3-chlorophenylacetic acid (21.76 g, 127.6 mmol) in dichloroethane (100 ml) was added MeOH (15.6 ml, 383 mmol) and H2SO4 (1 ml) at room temperature. After 20 minutes stirring, the mixture was heated at 80° C. for 2 h. The reaction mixture was poured into ice water and extracted with CHCl3. The combined extracts were washed with aq NaHCO3 and brine. After dried over Na2SO4, the extract was concentrated in vacuo to give methyl 3-chlorophenylacetate (25.4 g, 100%) as a colorless oil. 1H-NMR (CDCl3) δ3.60 (s, 2H), 3.70 (s, 3H), 7.15-7.26 (m, 4H).

1. extractionextracted with CHCl3
2. washThe combined extracts were washed with aq NaHCO3 and brine
3. dry with materialAfter dried over Na2SO4
4. concentrationthe extract was concentrated in vacuo

ORD-Eintrag

ord-0a2defb579d449558261c7a696e581b3

Quelldatensatz

uspto-grants-2004_06

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US06756378B2