2,3-Dimethyl-4-nitropyridine-N-oxide → Pyridine, 4-methoxy-2,3-dimethyl-, 1-oxide

HRID 35465

Reaktionsgleichung

Reaktionsgleichung von HRID 35465
[CH3:1][C:2]1[C:7]([CH3:8])=[C:6]([N+]([O-])=O)[CH:5]=[CH:4][N+:3]=1[O-:12].[CH3:13][O-:14].[Na+]>CO>[CH3:13][O:14][C:6]1[CH:5]=[CH:4][N+:3]([O-:12])=[C:2]([CH3:1])[C:7]=1[CH3:8]

Komponenten

4

Edukt 2

HCID 1482232,3-Dimethyl-4-nitropyridine-N-oxideHCID 10942334Sodium Methoxide

Produkt 1

HCID 10630707Pyridine, 4-methoxy-2,3-dimethyl-, 1-oxide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

A solution of 2.5 g (0.015 mol) of 2,3-dimethyl-4-nitropyridine 1-oxide in 50 ml of abs. methanol is treated with 0.883 g of sodium methylate, whereupon the mixture is stirred at room temperature under argon for 2 days. The reaction mixture is concentrated and the residue is extracted with methylene chloride and saturated sodium chloride solution. The methylene chloride phase is dried and evaporated. The residue, crystallized from methylene chloride/ ether, gives 4-methoxy-2,3-dimethylpyridine 1-oxide of melting point 80°-83°.

Aufarbeitung

  1. concentrationThe reaction mixture is concentrated
  2. extractionthe residue is extracted with methylene chloride and saturated sodium chloride solution
  3. dry with materialThe methylene chloride phase is dried
  4. customevaporated
  5. customThe residue, crystallized from methylene chloride/ ether

Quellen und Nachweise

ORD-Eintrag
ord-3bf28547df6047c298170f041a6da9a4
Quelldatensatz
uspto-grants-1988_08
Patentnummer
US04766133

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