Morpholine → 5,10-Dihydro-5-[3-morpholino-propionyl]-11H-dibenzo[b,e][1,4]diazepin-11-one

HRID 354785Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 354785
Cl[CH2:2][CH2:3][C:4]([N:6]1[C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][C:11]=2[C:10](=[O:17])[NH:9][C:8]2[CH:18]=[CH:19][CH:20]=[CH:21][C:7]1=2)=[O:5].[NH:22]1[CH2:27][CH2:26][O:25][CH2:24][CH2:23]1>C(O)(C)C>[O:25]1[CH2:26][CH2:27][N:22]([CH2:2][CH2:3][C:4]([N:6]2[C:12]3[CH:13]=[CH:14][CH:15]=[CH:16][C:11]=3[C:10](=[O:17])[NH:9][C:8]3[CH:18]=[CH:19][CH:20]=[CH:21][C:7]2=3)=[O:5])[CH2:23][CH2:24]1

Komponenten

4

Edukt 2

HCID 8083MorpholineHCID 128346825-(3-chloro-propionyl)-5,10-dihydro-11H-dibenzo[b,e][1,4]diazepin-11-one

Produkt 1

HCID 128347085,10-Dihydro-5-[3-morpholino-propionyl]-11H-dibenzo[b,e][1,4]diazepin-11-one

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3776IsopropanolLösungsmittel

Versuchsvorschrift

6.0 gm (0.02 mol) of 5-(3-chloro-propionyl)-5,10-dihydro-11H-dibenzo[b,e][1,4]diazepin-11-one and 10 gm (0.11 mol) of morpholine were refluxed in 200 ml of isopropanol for 2 hours. The solvent was distilled off, the residue was dissolved in methylene chloride, and the solution was washed with water. After distilling off the solvent, the residue was recrystallized from isopropanol.

Aufarbeitung

  1. distillationThe solvent was distilled off
  2. dissolutionthe residue was dissolved in methylene chloride
  3. washthe solution was washed with water
  4. distillationAfter distilling off the solvent
  5. customthe residue was recrystallized from isopropanol

Quellen und Nachweise

ORD-Eintrag
ord-567c63c4e9f6495c94be736fc85b4f6d
Quelldatensatz
uspto-grants-1983_03
Patentnummer
US04377576

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