Formamide → 4-Aminoquinazoline

HRID 354843

Reaktionsgleichung

Reaktionsgleichung von HRID 354843
[NH2:1][C:2]1[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=1[C:4]#[N:5].[CH:10]([NH2:12])=O>>[NH2:5][C:4]1[C:3]2[C:2](=[CH:9][CH:8]=[CH:7][CH:6]=2)[N:1]=[CH:10][N:12]=1

Komponenten

3

Edukt 2

HCID 713FormamideHCID 729132-Aminobenzonitrile

Produkt 1

HCID 847594-Aminoquinazoline

Reaktionsbedingungen

Temperatur
220 °C

Versuchsvorschrift

A mixture of o-aminobenzonitrile (22.58 g) and formamide (96 ml) was refluxed for 2 hours at 220° C. After the resultant mixture was cooled to ambient temperature, precipitated crystals were separated by filtration, washed twice with a small volume of water and dried under reduced pressure to give crystalline 4-aminoquinazoline (17.0 g).

Aufarbeitung

  1. customprecipitated crystals
  2. customwere separated by filtration
  3. washwashed twice with a small volume of water
  4. customdried under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-5deb0920a34d494fb43b1e7b80c6165f
Quelldatensatz
uspto-grants-1983_03
Patentnummer
US04377580

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